学 术 报 告
Optical Coherence Tomography (OCT)
Technology, Application, and Translation
报告人：YuChen, Associate Professor
(Fischell Department of Bioengineering, University ofMaryland, College Park, MD 20742, USA)
Optical CoherenceTomography (OCT) is an established medical imaging technology which isanalogous to ultrasound imaging but has significantly higher resolution (~10 mm)to enable 3D imaging of tissue microstructures in situ and in real-time with apenetration depth of ~1-2 mm. OCT can be extended to functional imagingmodalities such as Doppler OCT (DOCT) for blood flow detection andpolarization-sensitive OCT (PS-OCT) for detection of tissue birefringence. Wehave developed a forwarding-imaging needle-type OCT probe for avoiding thehemorrhage and guiding neurosurgical interventions. The needle probe has a thindiameter of 0.7 mm. The feasibility of vessel detection and neurosurgicalguidance were demonstrated on sheep brain in vivo and human brain ex vivo. Inaddition, we further reduced the probe size to 0.3 mm using an optical Dopplersensing (ODS) fiber probe that can integrate with microelectrode recording(MER) to detect the blood vessels lying ahead to improve the safety of thisprocedure. We further combine high-resolution OCT with large-field-of-viewmagnetic resonance imaging (MRI) to provide multi-scale imaging.
Dr. Yu Chen received his BS inPhysics from Peking University in 1997 and his PhD in Bioengineering from theUniversity of Pennsylvania in 2003. From 2003-2007, he pursued his postdoctoraltraining at MIT. He became an Assistant Professor of the Fischell Department ofBioengineering at the University of Maryland in College Park in 2007 and becamean Associate Professor since 2014. He has mentored 8 PhD students and 7postdoctoral fellows. He received Teaching Excellence Award from the FischellDepartment of Bioengineering of the University of Maryland in 2011, and theNational Science Foundation (NSF) CAREER Award in 2012. Dr. Chen has published1 book, 16 book chapters, and 93 peer-reviewed journal publications. He hasbeen an associate editor of Medical Physics, a guest editor of IEEE Journal ofSelected Topics on Quantum Electronics, Journal of Innovative Optical Health Sciences,Neurophotonics, and an Editorial Board member of Scientific Reports. He is amember of IEEE, SPIE, and a senior member of Optical Society of America (OSA).He has served as conference program co-chair and general co-chair for OSAConference on Lasers and Electro-Optics (CLEO): Applications and Technologies.